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Manufacture of Tablets: Wet Granulation, Direct Compression, Soluble and Chewable

1. Aim

To study the Year 3 practical manufacture of tablets: wet granulation, direct compression, soluble and chewable using the assigned verified method and document its outcome. Actual product or compound must be entered in the student record.

2. Requirements

Instructor-approved master formula or monograph, authenticated sample or teaching data, calibrated apparatus, control and quality records, observation sheet, protective equipment, and local waste instructions. Use the approved master formula for substances, quantities, process settings, and software. Acceptance limits and any unconfirmed drug identity are to be recorded from the assigned current monograph or approved college method in the student record.

3. Theory

The syllabus groups four tablet types in one numbered entry. Their excipients and process controls differ: wet granulation introduces a granulation and drying stage; direct compression depends on blend properties; soluble and chewable tablets have product-specific performance needs. A common label does not imply a common formula.

4. Procedure

Confirm the exact syllabus entry and the instructor-selected compound, formulation, or test.
Read the current approved method, risk controls, material identities, and equipment status before work.
Confirm which of the four types is assigned and obtain its approved master formula. Trace weighing, blending, any granulation, compression, and required in-process checks on the batch record. Complete physical work only under supervision.
Record raw observations, controls, sample identifiers, and any deviation without replacing missing values with assumptions.
Calculate only where the validated method, units, and actual inputs support it.
State the supported result and all missing details marked Record here.

5. Observation and calculation

Student record field	Entry
Case or product	Record here
Method	Record here
Observation	Record here
Inference	Record here
Supervisor check	Record here
Outcome	Record here

Assumed values or observations for practice only: Assumed target tablet mass is 200 mg and assumed measured mass is 198 mg. Assumed difference is negative 2 mg. These invented values are not a formula or quality decision. Every invented input and output is assumed and is not an actual manufacturing instruction or release result.

6. Output or final result

Submit a labelled four tablet routes and a conditional result. Record the supervised outcome here.

Teaching-lab safety: Any synthesis, manufacture, or testing requires teaching-lab supervision, approved hazards review, and local disposal. Sterile or injectable products are not for human use. Software-dependent work requires the approved lab system.

This page is a supervised-activity guide; it does not report a completed case.

7. Sources

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Theory notes: Pharm D Year 3, Pharmaceutical Formulations